Artemisinin-d4

Chemical Name:Artemisinin-d4
Synonyms:(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epox12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one-d4; Artemisine-d4; Arteannuin-d4; Huanghuahaosu-d4; QHS-d4
Molecular Formula:C₁₅H₁₈D₄O₅
Molecular Weight:286.36
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Artemisinin-d4 is the labelled form of Artemisinin (A777500). Artemisinin is an active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial. Artemisinin-d4 is also an intermediate in the synthesis of Dihydro Artemisinin-d3 (Dihydro Artemisinin-d3), which is the main labelled metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite.
References:e Vries, P., et al.: Drugs, 52, 818 (1996); Kamolrat, S., et al.: Antimicrob. Agents Chemother., 47, 3795 (2003); Mithwani, S., et al.: Br. J. Clin. Pharmacol., 57, 146 (2004)
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