Ataciguat

Chemical Name:Ataciguat
Synonyms:5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide; HMR 1766;
CAS Number:254877-67-3
Molecular Formula:C₂₁H₁₉Cl₂N₃O₆S₃
Molecular Weight:576.49
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.
References:Butt, E., et al.: J. Biol. Chem., 269, 14509 (1994),
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