Atorvastatin Epoxy Pyrrolooxazin Tricyclic Potassium Salt Impurity (>85%)

Chemical Name:Atorvastatin Epoxy Pyrrolooxazin Tricyclic Potassium Salt Impurity (>85%)
Synonyms:Atorvastatin Impurity; Sodium 2-(9-(4-Fluorophenyl)-1b-isopropyl-9a-phenyl-1a-(phenylcarbamoyl)octahydro-1aH-5,9-epoxyoxireno[2′,3′:3,4]pyrrolo[2,1-b][1,3]oxazocin-3-yl)acetate;
Impurity
Atorvastatin Impurity
Molecular Formula:C₃₃H₃₂FKN₂O₆
Appearance:Pale Yellow to Brown Solid
Melting Point:>157°C (dec.)
Molecular Weight:610.71
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A photodegadation product of Atorvastatin (a cyclic impurity of Atorvastatin (A791750)), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References:Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),
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