Bisoprolol Dihydrogen Phosphate Bis Sodium Salt

Chemical Name:Bisoprolol Dihydrogen Phosphate Bis Sodium Salt
Synonyms:Bisoprolol Impurity 11; Sodium 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-yl Phosphate;
Molecular Formula:C₁₈H₃₀NNa₂O₇P
Molecular Weight:449.36
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Bisoprolol Dihydrogen Phosphate is an impurity of Cardensiel (C667250). Cardensiel is an intermediate in the synthesis of 3,3′-(Isopropylazanediyl)bis(1-(4-((2-isopropoxyethoxy)methyl)phenoxy)propan-2-ol) (I824005), which is an impurtiy of Bisoprolol (B510500), a selective β-adrenergic blocker. Used as an antihypertensive.
References:Tattersfield, A.E., et al.: Brit. J. Clin. Pharmacol., 18, 343 (1984), Kohli, R.S., et al.: Eur. Heart J., 6, 845 (1985), Zachariah, P.K., et al.: Clin. Ther., 15, 779 (1993),
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