CAS:1001264-89-6|(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

Catalogue Number:C377870
Chemical Name:(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
Synonyms:GDC-0068; Ipatasertib; RG 7440;
CAS Number:1001264-89-6
Molecular Formula:C₂₄H₃₂ClN₅O₂
Appearance:Peach Solid
Melting Point:>106°C (dec.)
Molecular Weight:458
Storage:4°C, Hygroscopic
Solubility:Acetonitriele (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
References:Jie, L., et al.: Clin. Cancer. Res., 10, 1078 (2013);
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