CAS:1013330-79-4|N-[[4-[[(4-Amino[1,1′-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester

Catalogue Number:A601630
Chemical Name:N-[[4-[[(4-Amino[1,1′-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester
CAS Number:1013330-79-4
Molecular Formula:C₂₂H₂₁N₃O₃
Appearance:White Solid
Melting Point:172-174°C
Molecular Weight:375.42
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-[[4-[[(4-Amino[1,1′-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester is a biaryl benzamides that exhibit inhibitory selectivity over class II Histone Deacetylase (HDACs) and as well as class I HDACs. N-[[4-[[(4-Amino[1,1′-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester was deteremined to be a potent and selective inhibitor of HDAC with reduced off-target activity and tumor growth inhibition activity.
References:Witter, D.J., et al.: Bioorg. Medn. Chem. Letters., 18, 726 (2008);
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