CAS:1013916-37-4|2-​Chloro-​8-​cyclopentyl-​5-​methyl-​8H-​pyrido[2,​3-​d]​pyrimidin-​7-​one

Catalogue Number:C585608
Chemical Name:2-​Chloro-​8-​cyclopentyl-​5-​methyl-​8H-​pyrido[2,​3-​d]​pyrimidin-​7-​one
Synonyms:2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one;
CAS Number:1013916-37-4
Molecular Formula:C₁₃H₁₄ClN₃O
Appearance:Yellow to Dark Yellow Solid
Melting Point:176 – 178°C
Molecular Weight:263.72
Storage:-20°C, Inert atmosphere
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-​Chloro-​8-​cyclopentyl-​5-​methyl-​8H-​pyrido[2,​3-​d]​pyrimidin-​7-​one is an impurity of Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References:Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);
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