CAS:10517-21-2|5-Chloroindole-2-carboxylic Acid

CAS:10517-21-2|5-Chloroindole-2-carboxylic Acid

Catalogue Number:C377710
Chemical Name:5-Chloroindole-2-carboxylic Acid
Synonyms:5-Chloro-1H-indole-2-carboxylic Acid; 2-Carboxy-5-chloroindole; NSC 75651
CAS Number:10517-21-2
Molecular Formula:C₉H₆ClNO₂
Appearance:Beige Solid
Melting Point:>200ºC (dec.)
Molecular Weight:195.6
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of bII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.
References:Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)
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