CAS:1083065-04-6|7-Amino-5,7-dihydro-5-[(4-methoxyphenyl)methyl]-6H-dibenz[b,d]azepin-6-one Hydrochloride

Catalogue Number:A604465
Chemical Name:7-Amino-5,7-dihydro-5-[(4-methoxyphenyl)methyl]-6H-dibenz[b,d]azepin-6-one Hydrochloride
CAS Number:1083065-04-6
Alternate CAS #
Free Base: 847926-45-8
Molecular Formula:C₂₂H₂₀N₂O₂ •HCl
Appearance:Off-White to Pale Yellow Solid
Melting Point:>215°C (dec.)
Molecular Weight:344.41+(36.46)
Storage:4°C
Solubility:Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:7-Amino-5,7-dihydro-5-[(4-methoxyphenyl)methyl]-6H-dibenz[b,d]azepin-6-one Hydrochloride is an intermediate in the synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors for treatment of Alzheimer’s disease. Several γ-secretase inhibitors have been described that contain this compound.
References:Beher, D., et al.: Exp. Opin. Investig. Drugs, 14, 1385
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