CAS:110936-07-7|(1R-trans)-2-Chloro-N-propyl-N-(1,2,3,4-tetrahydro-1-hydroxy-7-methoxy-2-naphthalenyl)-acetamide

Catalogue Number:C380993
Chemical Name:(1R-trans)-2-Chloro-N-propyl-N-(1,2,3,4-tetrahydro-1-hydroxy-7-methoxy-2-naphthalenyl)-acetamide
CAS Number:110936-07-7
Molecular Formula:C₁₆H₂₂ClNO₃
Molecular Weight:311.80
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(1R-trans)-2-Chloro-N-propyl-N-(1,2,3,4-tetrahydro-1-hydroxy-7-methoxy-2-naphthalenyl)-acetamide is an intermediate in the synthesis of Naxagolide Hydrochloride (N379800), which is a dopamine D2-receptor agonist. Used for treatment of extrapyramidal disorders. Antiparkinsonian drug.
References:Fujita, N., et al.: Brain Res., 333, 231 (1985); Weiss, F., et al.: Eur. J, Pharmacol., 337, 219 (1997); Wilson, A., et al.: J. Med. Chem., 48, 4153 (2005); Ginovart, N., et al.: J. Neurochem., 97, 1089 (2006); Willeit, M., et al.: Biol. Psychiatry, 59, 389 (2006)
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