CAS:1131996-12-7|Apixaban-d3

Catalogue Number:A726703
Chemical Name:Apixaban-d3
Synonyms:4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide-d3; BMS 562247-01-d3; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid Amide-d3;
CAS Number:1131996-12-7
Alternate CAS #
503612-47-3 Unlabelled
Molecular Formula:C₂₅H₂₂D₃N₅O₄
Appearance:White to Off-White Solid
Melting Point:235 – 237°C
Molecular Weight:462.52
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Apixaban-d3 is labelled Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References:Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);
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