CAS:115066-14-3|6-Cyano-7-nitroquinoxaline-2,3-dione

Catalogue Number:C982000
Chemical Name:6-Cyano-7-nitroquinoxaline-2,3-dione
Synonyms:1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile; CNQX; 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;
CAS Number:115066-14-3
Molecular Formula:C₉H₄N₄O₄
Appearance:Pale Yellow to Light Yellow Solid
Melting Point:>300°C
Molecular Weight:232.15
Storage:4°C
Solubility:DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
Stability
Store Tightly Sealed at RT, Store Tightly Sealed At Rt
Category:Standards; Neurochemicals;
Applications:A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively.
References:Honore, et al. Science, 241, 701 (1988),Haas, H.S., et al.: Int. J. Oncol., 27, 867 (2005), Kobayashi, K., et al.: J. Pharmacol. Sci., 108, 517 (2008), Shabat-Simon, M., et al.: J. Neurosci., 28, 8406 (2008), Cruz, L.A., et al.: J. Med. Chem., 51, 5856 (2008),
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