CAS:1174733-90-4|1-(5-O-Acetyl-b-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one

Catalogue Number:A188035
Chemical Name:1-(5-O-Acetyl-b-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one
Synonyms:(5-O-Acetyl-β-D-ribofuranosyl)-Azacytidine;
CAS Number:1174733-90-4
Molecular Formula:C₁₀H₁₄N₄O₆
Appearance:White to Off-White Solid
Melting Point:>142°C (dec.)
Molecular Weight:286.24
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Moisture Sensitive
Category:Research Tools; Molecular Biology; Nucleic Acids; Enzyme Activators and Inhibitors;
Applications:1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one is an impurity of 5-Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.
References:Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)
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