CAS:120570-05-0|(3S)-Aminoquinuclidine

Catalogue Number:A628775
Chemical Name:(3S)-Aminoquinuclidine
Synonyms:(S)-1-Azabicyclo[2.2.2]oct-3-ylamine; (S)-3-Amino-1-azabicyclo[2.2.2]octane; (S)-3-Aminoquinuclidine; (S)-Quinuclidin-3-amine; (S)-(-)-3-Aminoquinuclidine; (3S)-1-Azabicyclo[2.2.2]octan-3-amine; (3S)-1-Azabicyclo[2.2.2]octan-3-amine; (S)-1-Azabicyclo[2.2.2]octan-3-amine;
CAS Number:120570-05-0
Molecular Formula:C₇H₁₄N₂
Molecular Weight:126.2
Category:Building Blocks; Miscellaneous;
Applications:(3S)-Aminoquinuclidine is an intermediate used in the synthesis of Palonosetron-3-ene Hydrochloride (P165825), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References:Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)
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