CAS:1210427-82-9|2′-Deoxy-3′,5′-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]cytidine

Catalogue Number:D249960
Chemical Name:2′-Deoxy-3′,5′-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]cytidine
CAS Number:1210427-82-9
Molecular Formula:C₂₈H₅₇N₃O₅Si₃
Molecular Weight:600.03
Solubility:DCM, Ethanol
Category:Research Tools; Carbohydrates and Oligosaccharides;
Applications:2′-Deoxy-3′,5′-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]cytidine is an intermediate in the synthesis of modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples.
References:Peng, X. et al.: J. Am. Chem. Soc., 130, 10299 (2008); Berkner, K. et al.: J. Biol. Chem., 252, 3185 (1977); Le, T. et al.: Anal. Biochem., 412, 203 (2011);
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