Catalogue Number:B367500
Chemical Name:BGT 226
Synonyms:NVP BGT226; NYP-BGT 226; 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-2H-Imidazo[4,5-c]quinolin-2-one (2Z)-2-Butenedioate (1:1); 8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one Maleate
CAS Number:1245537-68-1
Molecular Formula:C₃₂H₂₉F₃N₆O₆
Appearance:White to Pale Yellow Solid
Melting Point:>215°C (dec.)
Molecular Weight:650.6
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly)
Category:Research Tools;
Applications:BGT 226 is a novel phosphatidyl inositol-3 kinase/mammalian target of rapamycin (PI3K/mTOR ) dual inhibitor which has shown to be effective with gefitinib in epidermal growth factor receptor (EGFR) inhibitor-sensitive non-small cell lung cancer (NSCLC) therapy.
References:Katanasaka, Y., et. al.: Cancer Lett., 347, 196 (2014)
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