CAS:1246956-18-2|3-Desbenzoyl-3-hydroxybenzyl Nepafenac

Catalogue Number:D204105
Chemical Name:3-Desbenzoyl-3-hydroxybenzyl Nepafenac
Synonyms:2-Amino-3-(hydroxyphenylmethyl)-benzeneacetamide; Nepafenac Impurity E; 2-(2-Amino-3-(hydroxy(phenyl)methyl)phenyl) Acetamide;
Impurity:Nepafenac Impurity E
CAS Number:1246956-18-2
Molecular Formula:C₁₅H₁₆N₂O₂
Appearance:White to Off-White Solid
Melting Point:191 – 195°C
Molecular Weight:256.3
Storage:4°C
Solubility:Dichloromethane (Slightly), DMSO (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-Desbenzoyl-3-hydroxybenzyl Nepafenac is an impurity of Nepafenac (N390080), which is a selective COX-2 inhibitor, non-steroidal anti-inflammatory drug (NSAID) with analgesic activity. Nepafenac is also prodrug of Amfenac (A576500).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Walsh, D.A., et al.: J. Med. Chem., 33, 2296 (1990); Gamache, D.A., et al.: Inflammation, 24, 357 (2000); Lindstrom, R., et al.: Curr. Med. Res. Opin., 22, 397 (2006); Runje, M., et al.: J Pharm Biomed Anal, 123, 42 (2016);
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