CAS:125198-40-5|1-Cyclopropane Mycophenolic Acid

Catalogue Number:C989230
Chemical Name:1-Cyclopropane Mycophenolic Acid
Synonyms:3-(2-((4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)-1-methylcyclopropyl)propanoic Acid; 2-[(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)methyl]-1-methyl-cyclopropanepropanoic Acid
CAS Number:125198-40-5
Molecular Formula:C₁₈H₂₂O₆
Appearance:Off-White to Pale Yellow Solid
Melting Point:141-144*C
Molecular Weight:334.36
Storage:-20°C, Hygroscopic
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-Cyclopropane Mycophenolic Acid is a non-active analogue of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
References:Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)
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