CAS:1256585-15-5|Alectinib-d8

Catalogue Number:A521182
Chemical Name:Alectinib-d8
Synonyms:9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl-2,2,3,3,5,5,6,6-d8)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
CAS Number:1256585-15-5
Alternate CAS #
1256580-46-7
Molecular Formula:C₃₀H₂₆D₈N₄O₂
Appearance:White to Off-White Solid
Melting Point:>265°C (dec.)
Molecular Weight:490.67
Storage:4°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Alectinib-d8 is the labelled analogue of Alectinib (C183365, HCl), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Also is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
References:Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);
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