CAS:1264032-88-3|(3S)-1-Azabicyclo[2.2.2]octan-3-carbonochloridate

CAS:1264032-88-3|(3S)-1-Azabicyclo[2.2.2]octan-3-carbonochloridate

Catalogue Number:A795390
Chemical Name:(3S)-1-Azabicyclo[2.2.2]octan-3-carbonochloridate
Synonyms:(1R,3S,4R)-Quinuclidin-3-yl Carbonochloridate
CAS Number:1264032-88-3
Molecular Formula:C₈H₁₂ClNO₂
Molecular Weight:189.64
Category:Building Blocks; Chiral Molecules;
Applications:(3S)-1-Azabicyclo[2.2.2]octan-3-carbonochloridate is an intermediate in the synthesis of (1R,3S)-Solifenacin Succinate (S676695) which is an impurity of Solifenacin Succinate (S676701), a muscarinic M3 receptor antagoinst and used in treatment of urinary incontinence.
References:Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002), Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004), Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005), Habb, F., et al.: Eur. Urol. 47, 376 (2005), Payne, C.K., et al.: Drugs, 66, 175 (2006),
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