CAS:1296212-29-7|5-Dehydro Tolvaptan-d7

Catalogue Number:D230352
Chemical Name:5-Dehydro Tolvaptan-d7
Synonyms:N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide-d7; 1H-1-Benzazepine, Benzamide Deriv.-d7; 7-Chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-Oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-d7
CAS Number:1296212-29-7
Alternate CAS #
137973-76-3
Molecular Formula:C₂₆H₁₆D₇ClN₂O₃
Appearance:Off-white Solid
Molecular Weight:453.97
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-Dehydro Tolvaptan-d7 is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References:Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)
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