CAS:135635-50-6|Deshydroxy Tarcolimus

Catalogue Number:D119880
Chemical Name:Deshydroxy Tarcolimus
Synonyms:Tarcolimus Impurity IX
CAS Number:135635-50-6
Molecular Formula:C₄₄H₆₉NO₁₁
Molecular Weight:788.02
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Deshydroxy Tarcolimus is an impurity of Tacrolimus(F370000). Tacrolimus is an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
References:Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)
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