CAS:13700-02-2|2-Chloroethyl Methanethiosulfonate

Catalogue Number:C366125
Chemical Name:2-Chloroethyl Methanethiosulfonate
Synonyms:Methanesulfonothioic Acid S-(2-Chloroethyl) Ester; 2-Chloro-ethanethiol Methanesulfonate;
CAS Number:13700-02-2
Molecular Formula:C₃H₇ClO₂S₂
Appearance:Clear Colourless Oil
Melting Point:N/A
Molecular Weight:174.67
Storage:4°C, Hygroscopic
Solubility:Chloroform, Ethyl Acetate
Stability
Moisture Sensitive
Category:Research Tools; Sulfhydryl Active Reagents;
Applications:Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor.
References:Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Holmgren, M. et al: Neuropharmacology, 35, 797 (1996) Chahine, M. et al.: Biochemical & Biophysical Res. Commun., 233, 606 (1997), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Rassendren, F., et al.: The EMBO Journal, 16, 3446 (1997), Egan, T.M., et al.: The Journal of Neuroscience, 18(7), 2350 (1998), Lin, C.-W. and Tsung-Yu, C.: J. Gen. Physiol., 116, 535 (2000)
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