CAS:1375105-27-3|N-[4-Cyano-2-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide

Catalogue Number:C778035
Chemical Name:N-[4-Cyano-2-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide
CAS Number:1375105-27-3
Molecular Formula:C₁₂H₉F₃N₂O₂
Appearance:White to Off-White Solid
Melting Point:93-96°C
Molecular Weight:270.21
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-[4-Cyano-2-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide is a useful intermediate in the preparation of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents which are potential anti-tumor drugs.Positional isomer of C987585
References:Pertusati, F., et al.: Eur. J. Med. Chem., 180, 1 (2019); Bassetto, M., et al.: Eur. J. Med. Chem., 118, 230 (2016)
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