CAS:1382839-19-1|5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol

Catalogue Number:A633195
Chemical Name:5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol
CAS Number:1382839-19-1
Molecular Formula:C₁₀H₁₇NO₂
Appearance:White to Off-White Solid
Melting Point:>246°C (dec.)
Molecular Weight:183.25
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.
References:Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)
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