Catalogue Number:C366942
Chemical Name:4-Chloro Kynurenine-13C2,15N
Synonyms:α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; 4-Cl-KYN-13C2,15N; (+/-)-AV-101-13C2,15N;
CAS Number:1391051-72-1
Alternate CAS #
75802-84-5-unlabelled
Molecular Formula:C₈¹³C₂H₁₁ClN¹⁵NO₃
Appearance:Pale Yellow to Light Yellow Solid
Melting Point:>195°C
Molecular Weight:245.64
Storage:-20°C, Hygroscopic
Solubility:Aqueous Acid (Slightly)
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.
References:Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),
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