CAS:1469-28-9|8-Chlorodibenzo[b,f]thiepin-10(11H)-one

Catalogue Number:C363760
Chemical Name:8-Chlorodibenzo[b,f]thiepin-10(11H)-one
Synonyms:8-Chlorodibenzo[b,f]thiepin-10(11H)-one; 2-Chloro-10,11-dihydrodibenzo[b,f]thiepin-11-one; 8-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-one; 8-Chloro-10,11-dihydrodibenzo[b,f]thiepin-2-one;
CAS Number:1469-28-9
Molecular Formula:C₁₄H₉ClOS
Appearance:Off-White to Yellow Solid
Melting Point:121-124°C
Molecular Weight:260.74
Storage:4°C
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:8-Chlorodibenzo[b,f]thiepin-10(11H)-one is an intermediate in the synthesis of Zotepine-d6, which is the labeled analogue of Zotepine (Z700900), an atypical antipsychotic drug used for the treatment of acute and chronic schizophrenia, and acute bipolar mania. It acts as antagonist at dopamine and serotonin receptors. It has a high affinity for the D1 and D2 receptors.
References:Chan, H, et al.: Psychiat. Clinical Neurosciences 64 (2), 162 (2010); Harada, T., et al.; Clinical Therapeutics 8 (4), 406 (1986);
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