CAS:149888-94-8|Azimilide Dihydrochloride

Catalogue Number:A926950
Chemical Name:Azimilide Dihydrochloride
Synonyms:1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione Dihydrochloride; NE 10064 Dihydrochloride
CAS Number:149888-94-8
Alternate CAS #
Free Base: 149908-53-2
Molecular Formula:C₂₃H₃₀Cl₃N₅O₃
Appearance:Light Yellow-Green Solid
Melting Point:>226°C (dec.)
Molecular Weight:530.88
Storage:4°C, Hygroscopic
Solubility:Methanol (Heated), Water (Heated)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Azimilide Dihydrochloride is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Tran, H.T., et al.: Heart. Dis., 1, 114 (1999); Conway, E., et al.: Am. J. Cardiol., 102, 12 (2008); Carlson, M., et al.: Exp. Rev. Cardio. Therap., 3, 387 (2005); Dorian, P., et al.: J. Cardio. Pharm. Therap., 7, 211 (2002);
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