CAS:15159-65-6|(S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide (~90%)

Catalogue Number:A602465
Chemical Name:(S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide (~90%)
Synonyms:(2S)-2-Amino-4-bromobutyric Acid Hydrobromide; (S)-2-Amino-4-bromobutyric Acid Hydrobromide; L-2-Amino-4-bromobutyric Acid Hydrobromide;
CAS Number:15159-65-6
Alternate CAS #
Free base: 92136-58-8
Molecular Formula:C₄H₈BrNO₂ • (HBr)
Appearance:White to Light Brown Solid
Melting Point:173-176°C
Molecular Weight:182.02 + (80.91)
Storage:-20°C
Solubility:DMF (Slightly), DMSO, Methanol (Slightly)
Stability
Hygroscopic, Moisture Sensitive, Unstable in Solution
Category:Building Blocks; Chiral Molecules;
Applications:(S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide is a building block used in stereoselective preparation of phosphinic acid phosphapeptide analogs of glutamyl-γ-glutamate as potent inhibitors of folylpolyglutamate synthetase. Also used in the synthesis of isoindoline carbamate and acylsulfonamide containing macrocyclic peptidomimetics as inhibitors of HCV NS3/4A protease.
References:Bartley, D., et al.: J. Org. Chem., 70, 6757 (2005); Jiang, Y., et al.: J. Med. Chem., 57, 1753 (2014);
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