CAS:158878-47-8|Cerivastatin lactone

Catalogue Number:C277005
Chemical Name:Cerivastatin lactone
Synonyms:[4R-[4α,6β(E)]]-6-[2-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; (4R,6S)-6-((E)-2-(4-(4-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one; (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one
CAS Number:158878-47-8
Molecular Formula:C₂₆H₃₂FNO₄
Appearance:White to Off-White Solid
Melting Point:104-106°C
Molecular Weight:441.53
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Cerivastatin lactone is a metabolite of a competitive inhibitor of HMG-CoA reductase, Cerivastatin (C277000). Cerivastatin lactone shows inhibitory effects on CYP3A4/5 activity.
References:Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996); Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996); Sakaeda, T., et. al.: Pharmaceut. Res., 23, 506 (2006)
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