CAS:1619233-32-7|(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one 2,2,2-Trifluoroacetate

Catalogue Number:A604805
Chemical Name:(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one 2,2,2-Trifluoroacetate
CAS Number:1619233-32-7
Molecular Formula:C₁₁H₁₈F₃NO₃
Molecular Weight:269.26
Category:Building Blocks;
Applications:(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one 2,2,2-Trifluoroacetate is a reagent used for carbonyls and epoxides as dual electrophiles in peptide-based proteasome inhibitors. This is also an impurity of carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References:Xin, B., et al.: Org. Biomol. Chem., 12, 5710 (2014); Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);
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