CAS:1620494-31-6|Desmethyl-O-Benzyl Apixaban

Catalogue Number:D119845
Chemical Name:Desmethyl-O-Benzyl Apixaban
Synonyms:1-(4-(Benzyloxy)phenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
CAS Number:1620494-31-6
Molecular Formula:C₃₁H₂₉N₅O₄
Appearance:Pale Beige to Light Brown Solid
Melting Point:>131°C (dec.)
Molecular Weight:535.59
Storage:4°C, Inert atmosphere
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Desmethyl-O-Benzyl Apixaban is a useful intermediate in the preparation of Apixaban (A726700). Apixaben is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation. Apixaban Impurity.
References:Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011); Bhirud, S. B., et al.:From U.S. Pat. Appl. Publ.(2015),US20150353543A120151210
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