CAS:162758-35-2|5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid

Catalogue Number:C377830
Chemical Name:5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid
Synonyms:1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid; 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid;
CAS Number:162758-35-2
Molecular Formula:C₁₇H₁₁Cl₃N₂O₂
Appearance:White Solid
Melting Point:214-217°C
Molecular Weight:381.64
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid is used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists. It is metabolite M9 of Rimonabant (R517800), an antiobesity agent.
References:Kang, S.Y. et al.: Bioorg. Med. Chem. Lett., 18, 2385 (2008); Fulp, A. et al.: Bioorg. Med. Chem. Lett., 21, 5711 (2011); Bergstrom, M.A. et al.: Drug Metab. and Dispos., 39, 1823 (2011);
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