CAS:1628340-74-8|Acetoxy Ticagrelor Acetonide

CAS:1628340-74-8|Acetoxy Ticagrelor Acetonide

Catalogue Number:A445310
Chemical Name:Acetoxy Ticagrelor Acetonide
Synonyms:2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethyl Acetate
CAS Number:1628340-74-8
Molecular Formula:C₂₈H₃₄F₂N₆O₅S
Appearance:Glassy residue
Molecular Weight:604.67
Solubility:Chloroform
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Acetoxy Ticagrelor Acetonide is an intermediate in the synthesis of Ticagrelor Acetoxide (D232265) which is an acetoxy impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).
References:Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)
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