CAS:1675248-18-6|2-Descyano-2-ethyl Formyl-tofacitinib

Catalogue Number:D221590
Chemical Name:2-Descyano-2-ethyl Formyl-tofacitinib
Synonyms:Ethyl 3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate
CAS Number:1675248-18-6
Molecular Formula:C₁₈H₂₅N₅O₃
Appearance:White to Off-White Solid
Melting Point:>63°C
Molecular Weight:359.42
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Descyano-2-ethyl Formyl-tofacitinib is an impurity compound of Tofacitinib(C781351). Tofacitinib is a Janus kinase inhibitor for the treatment of rheumatoid arthritis.
References:Sheiner, L., et al.: Clin. Pharmacol. Ther., 25, 358 (1979), Dayneka, N., et al.: J. Pharmacokin. Biopharm., 21, 457 (1993), Changelian, P., et al.: Science, 302, 875 (2003), Lee, H., et al.: Clin. Pharmacol. Ther., 73, 348 (2003), Hutmacher, M., et al.: J. Clin. Pharmacol., 47, 238 (2007),
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