CAS:172732-52-4|2-(2-Cyanophenyl)-1,3,2-dioxaborinane

Catalogue Number:C987675
Chemical Name:2-(2-Cyanophenyl)-1,3,2-dioxaborinane
Synonyms:2-(1,3,2-Dioxaborinan-2-yl)benzonitrile;
CAS Number:172732-52-4
Molecular Formula:C₁₀H₁₀BNO₂
Appearance:White to Pale Beige Solid
Melting Point:54-56°C
Molecular Weight:187
Storage:4°C, Hygroscopic
Solubility:Chloroform (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Miscellaneous;
Applications:2-(2-Cyanophenyl)-1,3,2-dioxaborinane is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission. Also used in the small scale synthesis of Perampanel (P285520), an AMPA receptor antagonist.
References:Hibi, S. et al.: J. Med. Chem., 55, 10584 (2012); McElhinny, C. et al.: Synthesis, 44, 57 (2012);
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