CAS:1798888-56-8|Amino Nimesulide NAC Adduct Sodium Salt

Catalogue Number:A618515
Chemical Name:Amino Nimesulide NAC Adduct Sodium Salt
Synonyms:N-Acetyl-S-[2-amino-5-[(methylsulfonyl)amino]-4-phenoxyphenyl]-L-cysteine Sodium Salt
CAS Number:1798888-56-8
Alternate CAS #
Free Acid: 1094566-35-4
Molecular Formula:C₁₈H₂₀N₃NaO₆S₂
Appearance:Light Pink Solid
Melting Point:141-150°C
Molecular Weight:461.49
Storage:-20°C, Inert atmosphere
Solubility:DMSO, Methanol
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Amino Nimesulide is an analog of Nimesulide (N477500), an antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production.
References:Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)
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