CAS:1805587-94-3|4-​Amino-​2,​5-​bis(trifluoromethyl)​phenol

Catalogue Number:A633415
Chemical Name:4-​Amino-​2,​5-​bis(trifluoromethyl)​phenol
CAS Number:1805587-94-3
Molecular Formula:C₈H₅F₆NO
Appearance:Pale Yellow Solid
Melting Point:>130°C (sub.)
Molecular Weight:245.12
Storage:-20°C, Inert atmosphere, Light sensitive
Solubility:Chloroform (Slightly, Heated), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-​Amino-​2,​5-​bis(trifluoromethyl)​phenol is an intermediate in the synthesis of 4’-Hydroxy Dutasteride (H825530), which is an impurity of Dutasteride (D735000), a dual inhibitor of 5a-reductase isoenzymes type 1 and 2
References:Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995); Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999); Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005)
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