CAS:1881270-48-9|2-Amino-3-benzoyl-5-chloro-α-(propylthio)benzeneacetamide

CAS:1881270-48-9|2-Amino-3-benzoyl-5-chloro-α-(propylthio)benzeneacetamide

Catalogue Number:A593985
Chemical Name:2-Amino-3-benzoyl-5-chloro-α-(propylthio)benzeneacetamide
Synonyms:Nepafenac Impurity;
CAS Number:1881270-48-9
Molecular Formula:C₁₈H₁₉ClN₂O₂S
Molecular Weight:362.87
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Amino-3-benzoyl-5-chloro-α-(propylthio)benzeneacetamide is derived from Methyl Chloroacetate (M294960), which is widely used in the chemical and biochemical fields as an extraction solvent. Methyl chloroacetate is known to induce DNA damage to rat sperm, and is also thought to be toxic to humans upon exposure. Methyl chloroacetate is also used as a reagent to synthesize Valdecoxib (V090000), a selective cyclooxygenase 2(COX-2) specific inhibitor that is used to treat postoperative pain;Also, it is a non-steroidal anti-inflammatory drug (NSAID).
References:Nussmeier, N., et al.: New Engl. J. Med., 352, 1081 (2005); Talley, J., et al.: J. Med. Chem., 43, 775 (2000); Wang, T., et al.: J. Chromatogr. A, 1147, 105 (2007); Wenye, L.: J. Anh. Agri. Sci., 35, 2581 (2007); Runje, M., et al.: J. Pharm. Biomed. Anal., 123, 42-52 (2016)
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