CAS:197776-07-1|5-Chloro-2,3-dihydro-2-oxo-1H-indole-1-carboxylic Acid Ethyl Ester

Catalogue Number:C433053
Chemical Name:5-Chloro-2,3-dihydro-2-oxo-1H-indole-1-carboxylic Acid Ethyl Ester
Synonyms:Ethyl 5-Chloro-2-oxoindoline-1-carboxylate
CAS Number:197776-07-1
Molecular Formula:C₁₁H₁₀ClNO₃
Appearance:Brown Solid
Molecular Weight:239.66
Solubility:Dichloromethane, Ethyl Acetate, Methanol
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-Chloro-2,3-dihydro-2-oxo-1H-indole-1-carboxylic Acid Ethyl Ester is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3b inhibitors as anticancer agents.
References:Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);
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