CAS:20448-79-7|2-Amino-2-norbornanecarboxylic Acid

Catalogue Number:A619050
Chemical Name:2-Amino-2-norbornanecarboxylic Acid
Synonyms:2-Aminobicyclo[2.2.1]heptane-2-carboxylic Acid; 2-Aminonorbornane-2-carboxylic Acid;
CAS Number:20448-79-7
Molecular Formula:C₈H₁₃NO₂
Appearance:White Solid
Melting Point:>206°C (dec.)
Molecular Weight:155.19
Storage:4°C
Solubility:Aqueous Acid (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Amino-2-norbornanecarboxylic Acid functions in the suppressive effect of I-type amino acid transporter 1 inhibition as therapeutic target on human esophageal squamous cell carcinoma. Also use in the design and preparation of KMH-233, selective and slowly reversible inhibitor of L-type amino acid transporter 1 (LAT1) which potentiates antiproliferative drug efficacy in cancer cells
References:Ohshima, Y., et al.: Cancer Science, 107, 1499 (206); Huttunen, K. M., et al.: J. Med. Chem., 59, 5740 (2016)
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