CAS:2102097-05-0|N-​[3-​Cyano-​5-​(trifluoromethyl)​phenyl]​-​N’-​[trans-​4-​[4-​(trifluoromethyl)​phenoxy]​cyclohexyl]​urea

Catalogue Number:C321630
Chemical Name:N-​[3-​Cyano-​5-​(trifluoromethyl)​phenyl]​-​N’-​[trans-​4-​[4-​(trifluoromethyl)​phenoxy]​cyclohexyl]​urea
Synonyms:1-​((1,​4-​trans)​-​4-​Aryloxycyclohexyl)​-​3-​arylureas
CAS Number:2102097-05-0
Molecular Formula:C₂₂H₁₉F₆N₃O₂
Molecular Weight:471.4
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:N-​[3-​Cyano-​5-​(trifluoromethyl)​phenyl]​-​N’-​[trans-​4-​[4-​(trifluoromethyl)​phenoxy]​cyclohexyl]​urea acts as a specific activator of HRI (heme-regulated inhibitor) which triggers the eIF2a phosphorylation arm of endoplasmic reticulum (ER) stress response.
References:Yefidoff-Freedman, R. et al.: J. Med. Chem., 60, 5392-5406 (2017)
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