CAS:2254541-79-0|Crisaborole Diamer

CAS:2254541-79-0|Crisaborole Diamer

Catalogue Number:C659450
Chemical Name:Crisaborole Diamer
Synonyms:4,​4′-​[[2,​2′-​Bis(hydroxymethyl)​[1,​1′-​biphenyl]​-​4,​4′-​diyl]​bis(oxy)​]​bis-benzonitrile
CAS Number:2254541-79-0
Molecular Formula:C₂₈H₂₀N₂O₄
Molecular Weight:448.47
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:Crisaborole Diamer Impurity is an impurity of Crisaborole (H947928). Crisaborole is a series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-​(4-​Cyanophenoxy)​-​2,​3-​dihydro-​1-​hydroxy-​2,​1-​benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent.
References:Akama, T., et al.: Bioorganic Med. Chem. Lett., 19, 2129 (2009)
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