CAS:22608-11-3|(2E)-Demethoxy Curcumin

Catalogue Number:D230815
Chemical Name:(2E)-Demethoxy Curcumin
Synonyms:(E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; 1-(4-Hydroxy-3-methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione; (1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin; Demethoxycurcumin
CAS Number:22608-11-3
Molecular Formula:C₂₀H₁₈O₅
Appearance:Pink to Red Solid
Melting Point:178-180°C (dec.)
Molecular Weight:338.35
Storage:-20°C, Light sensitive, Light sensitive
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Light Sensitive
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/b-catenin pathway through down-regulation of the transcriptional coactivator p300.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Ryu, M.J. et al.: Biochem. Biophys. Res. Comm., 377, 1304 (2008); Sandur, S.K. et al.: Carcinogenesis, 28, 1765 (2007); Huang, T. et al.: J. Agric. Food. Chem., 58, 10639 (2010);
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