CAS:2475094-95-0|4-[(4-Chloro-3-fluorophenyl)amino]-6-nitroquinazolin-7-ol

Catalogue Number:C367565
Chemical Name:4-[(4-Chloro-3-fluorophenyl)amino]-6-nitroquinazolin-7-ol
Synonyms:4-​[(4-​Chloro-​3-​fluorophenyl)​amino]​-​6-​nitro-7-​quinazolinol; Afatinib Impurity:CAS Number:2475094-95-0
Molecular Formula:C₁₄H₈ClFN₄O₃
Molecular Weight:334.69
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-[(4-Chloro-3-fluorophenyl)amino]-6-nitroquinazolin-7-ol may be useful in the preparation of lung cancer drugs. It is a related compound of Afatinib (A355300), which is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References:Xiang, F., et al.: Faming Zhuanli Shenqing, 32pp. (2020); Schroeder, J., et al.: PCT Int. Appl. (2007); Nakao, K., et al.: Sci. Rep., 9, 18202 (2019); Ebert, K., et al.: PLoS One, 14, 0223225 (2019)
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