CAS:254452-96-5|(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt

Catalogue Number:C988855
Chemical Name:(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt
Synonyms:5-epi-NK-104;
CAS Number:254452-96-5
Alternate CAS #
769908-13-6
Molecular Formula:C₅₀H₄₆CaF₂N₂O₈
Appearance:Off-White to Beige Solid
Melting Point:189-191°C
Molecular Weight:881
Storage:-20°C
Solubility:Acetonitrile (Slightly), DMSO (Slightly)
Stability
Light Sensitive
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt is the 3R,5R- Isomer of Pitavastatin (P531000), a HMG CoA reductase inhibitor and an antilipemic agent.
References:Suzukim M., et al.: Bioorg. Med. Chem., 9, 2977 (1999); Yen, H., et al.: J. Clin. Invest., 98, 1253 (1996); Zou, Y., et al.: J. Biol. Chem., 274, 9760 (1999); Sun, X., et al.: Cancer Res., et al.: 61, 3382 (2001); Ladas, E.J., et al.: Clin. Oncol., 22, 517 (2004);
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