CAS:27064-96-6|Defluoro Flunarizine Dihydrochloride

Catalogue Number:D228700
Chemical Name:Defluoro Flunarizine Dihydrochloride
Synonyms:Flunarizine Impurity B Dihydrochloride; Flumazenil EP Impurity B Dihydrochloride;
Impurity:Flumazenil EP Impurity B
CAS Number:27064-96-6
Alternate CAS #
Free Base: 39245-25-5
Molecular Formula:C₂₆H₂₇FN₂ •2HCl
Appearance:Pale Orange to Light Orange Solid
Melting Point:>189°C (dec.)
Molecular Weight:386.50 +2(36.46)
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Defluoro Flunarizine (Flumazenil EP Impurity B) Dihydrochloride, is an impurity of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral).
References:Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984)
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