CAS:276870-95-2|2′-Deoxy-5′-O-[(1,1-dimethylethyl)diphenylsilyl]cytidine

Catalogue Number:D287835
Chemical Name:2′-Deoxy-5′-O-[(1,1-dimethylethyl)diphenylsilyl]cytidine
Synonyms:4-Amino-1-((2R,4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
CAS Number:276870-95-2
Molecular Formula:C₂₅H₃₁N₃O₄Si
Molecular Weight:465.62
Category:Building Blocks; Molecular Biology; Nucleic Acids; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2′-Deoxy-5′-O-[(1,1-dimethylethyl)diphenylsilyl]Cytidine is a useful intermediate in the synthesis of phosphorothioate nucleotides with applications in antisense oligonucleotide (ASO) therapeutics.
References:Knouse, K. W., et al.: Science , 361, 1234 (2018)
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