CAS:27912-10-3|trans-5-​[3-​(Dimethylamino)​propyl]​-​1,​2,​3,​4,​4a,​10,​11,​11a-​octahydro-​5H-​dibenzo[a,​d]​cyclohepten-​5-​ol

Catalogue Number:D182595
Chemical Name:trans-5-​[3-​(Dimethylamino)​propyl]​-​1,​2,​3,​4,​4a,​10,​11,​11a-​octahydro-​5H-​dibenzo[a,​d]​cyclohepten-​5-​ol
Synonyms:(4aR,11aS)-5-(3-(Dimethylamino)propyl)-2,3,4,4a,5,10,11,11a-octahydro-1H-dibenzo[a,d][7]annulen-5-ol
CAS Number:27912-10-3
Molecular Formula:C₂₀H₃₁NO
Molecular Weight:301.47
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:trans-5-​[3-​(Dimethylamino)​propyl]​-​1,​2,​3,​4,​4a,​10,​11,​11a-​octahydro-​5H-​dibenzo[a,​d]​cyclohepten-​5-​ol is an intermediate in the synthesis of trans-1,2,3,4,4a,10,11,11a-Octahydro-N,N-dimethyl-5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine Hydrochloride (Amitriptyline EP Impurity E) (O236425), which is an impurity of Amitriptyline (A633350), which is an antidepressant.
References:Blessel, K.W., et al.: Anal. Profiles Drug Subs., 3, 127 (1974), Tobe, A., et al.: Arzneim.-Forsch., 31, 1278 (1981),
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