CAS:28861-00-9|N-(Aminocarbonyl)-3-methoxy-O,α-dimethyl-L-tyrosine

Catalogue Number:A602760
Chemical Name:N-(Aminocarbonyl)-3-methoxy-O,α-dimethyl-L-tyrosine
Synonyms:L-4-(3,4-Dimethoxybenzyl)-4-methylhydantoic Acid; L-α-(3,4-Dimethoxybenzyl)-α-methylhydantoic Acid; L-α-Methyl-α-ureido-β-(3,4-dimethoxyphenyl)propionic Acid; L-N-Carbamoyl-3-(3,4-dimethoxyphenyl)-2-methyl-alanine;
CAS Number:28861-00-9
Molecular Formula:C₁₃H₁₈N₂O₅
Molecular Weight:282.29
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-(Aminocarbonyl)-3-methoxy-O,α-dimethyl-L-tyrosine is an intermediate used in the synthesis of (S)-(-)-Carbidopa (C175985), which is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.
References:Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);
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